Evaluation of single-use bioreactors for perfusion processes
نویسندگان
چکیده
Introduction Single-Use Bioreactors are now commonly used for Process Development activities, as seeding bioreactors or to produce Drug Substances. The advantages of this equipment have been well demonstrated over the last years on batch/fed-batch processes. Continuous processes were widely applied in the past to increase the overall productivity of small bioreactors or for sensitive molecule production. The process control, contamination risk and complexity were the main concerns of this operation mode. However, the bioprocessing trends and technology evolution led to reconsidering the perfusion processes. The aim of this study was to combine standard single-use bioreactors with different perfusion technologies and to compare productivity and molecule quality.
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